Two-time Olympic decathlete and Nobel Prize winner, Dr. Victor Fries studied molecular biology. Once his wife is diagnosed with MacGregor's Syndrome - a terminal illness - He then froze her in cryogenic stasis, as he searched for a cure to the illness. After finding ways to cure the early stages of the illness, not stopping until he could cure the late-stage his wife was in. During an experiment, an explosion pushed him into a vat of chemicals used to freeze his wife! He climbs out of the vat as Mr. Freeze.